ABCB11

Across TCGA cell cohorts, ABCB11 mutation is significantly associated with the RNA expression of many other genes, with 343 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCB11-associated genes across cancer lineages are C8orf86, PIMREG, and AFG1L. Each is linked with ABCB11 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCB11-to-partner and partner-to-ABCB11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C8orf86 grouped by ABCB11-low versus ABCB11-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB11→partner) and Y-score (partner→ABCB11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C8orf86 →	+0.037	+3.076	<.001	.002	3	2
LARGE_INTESTINE	PIMREG →	+0.880	+2.502	.001	.005	3	2
LARGE_INTESTINE	AFG1L →	+0.507	+3.237	.003	.003	3	2
LARGE_INTESTINE	FRA10AC1 →	+0.553	+3.628	.001	<.001	3	2
LARGE_INTESTINE	POC1A →	+0.459	+3.169	.003	.009	3	2
LARGE_INTESTINE	ISCA2 →	+0.367	+2.502	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 343 associations by consensus.

C8orf86 by ABCB11 expression — BLOOD_Leukemia

Explore this box plot interactively →