ABCA9

Across TCGA patient cohorts, ABCA9 mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCA9-associated genes across cancer lineages are HSP70, Cyclin-B1, and ASNS. Each is linked with ABCA9 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCA9-to-partner and partner-to-ABCA9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSP70 grouped by ABCA9-low versus ABCA9-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA9→partner) and Y-score (partner→ABCA9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HSP70 →	-0.612	-3.169	.037	.020	3	4
UCEC	Cyclin-B1 →	+0.675	+2.807	<.001	<.001	3	4
COAD	ASNS →	+0.696	+3.807	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.098	+3.476	<.001	.002	3	3
UCEC	C-Raf →	+0.166	+1.716	<.001	.003	3	3
UCEC	PDCD4 →	-0.406	-1.222	.002	.011	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

HSP70 by ABCA9 expression — BRCA

Explore this box plot interactively →