ABCA9

Across TCGA pan-cancer cohorts, ABCA9 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ABCA9’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ABCA9 RNA is repressed in tumor relative to normal tissue. In most cancer types ABCA9 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KIRC are the cancer types where ABCA9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCA9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−2.103	<.001	11	view →
COAD	All	III,IV	−1.076	<.001	11	view →
KIRC	All	II,III,IV	−0.581	<.001	10	view →
LUAD	Female	III,IV	−1.275	<.001	9	view →
KIRP	Female	All	−0.765	<.001	9	view →
UCEC	All	All	−2.623	<.001	8	view →
LUSC	Male	All	−1.641	<.001	8	view →
KICH	Female	All	−1.193	<.001	8	view →
BRCA	All	III,IV	−2.775	<.001	6	view →
BLCA	All	All	−1.400	.001	6	view →
HNSC	Male	All	−0.534	.004	6	view →
READ	All	All	−1.823	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ABCA9–THCA

Open the THCA breakdown →