Across TCGA patient cohorts, ABCA4 mutation is significantly associated with the RNA expression of many other genes, with 7,045 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCA4-associated genes across cancer lineages are CHAF1A, CDCA2, and DCLRE1B. Each is linked with ABCA4 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCA4-to-partner and partner-to-ABCA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA4→partner) and Y-score (partner→ABCA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1A →	+0.569	+1.991	<.001	<.001	3	5
UCEC	CDCA2 →	+0.672	+1.969	<.001	<.001	3	5
UCEC	DCLRE1B →	+0.413	+1.828	<.001	<.001	3	5
UCEC	RAN →	+0.312	+1.370	.004	.002	3	5
UCEC	KIF2C →	+0.440	+1.315	.005	<.001	3	5
UCEC	CCNA2 →	+0.632	+1.695	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,045 associations by consensus.

Exploration

ABCA4 survival (RNA) · tumor vs normal (RNA) · all ABCA4 data types