Across TCGA pan-cancer cohorts, ABCA4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ABCA4 data layer compared with 11 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ABCA4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ABCA4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

BLCA, KIRP, and SKCM are the cancer types where ABCA4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	All	0.247	0.552	<.001	116	view →
KIRP	DFS	Tertile	All	0.332	0.752	<.001	105	view →
SKCM	OS	Median	II,III,IV	0.672	0.796	<.001	40	view →
LUAD	DFS	Quartile	III,IV	0.805	0.493	.006	40	view →
MESO	OS	Quartile	II,III,IV	0.442	0.785	.002	39	view →
STAD	DFS	Quartile	II,III,IV	0.563	0.745	.002	36	view →
KIRC	DFS	Quartile	II,III,IV	0.410	0.675	<.001	34	view →
UCEC	OS	Tertile	IV	0.611	0.203	.006	24	view →
READ	OS	Median	II,III,IV	0.868	0.477	.013	22	view →
LUSC	DFS	Tertile	II,III,IV	0.746	0.281	.002	21	view →
THYM	DFS	Median	II,III,IV	0.969	0.811	.002	20	view →
LIHC	OS	Median	All	0.701	0.860	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

Exploration

Same gene, other analysis: ABCA4 tumor-vs-normal RNA expression · all ABCA4 data types