Across TCGA patient cohorts, ABCA4 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCA4-associated genes across cancer lineages are GAPDH, Shc_pY317, and Caspase-7-cleavedD198. Each is linked with ABCA4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCA4-to-partner and partner-to-ABCA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA4→partner) and Y-score (partner→ABCA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GAPDH →	+0.709	+2.009	.009	.018	3	4
UCEC	Shc_pY317 →	-0.110	-1.087	.004	.010	3	4
COAD	Caspase-7-cleavedD198 →	+1.227	+2.146	<.001	<.001	3	4
COAD	PAI-1 →	+0.516	+3.339	.004	.004	3	4
BRCA	4E-BP1_pS65 →	+0.309	+2.814	.006	.037	3	3
BLCA	JNK_pT183_Y185 →	-0.205	-3.000	.007	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Exploration

ABCA4 survival (RNA) · tumor vs normal (RNA) · all ABCA4 data types