Across TCGA cell cohorts, ABCA4 mutation is significantly associated with the RNA expression of many other genes, with 177 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCA4-associated genes across cancer lineages are REG3G, AWAT2, and SLC36A2. Each is linked with ABCA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCA4-to-partner and partner-to-ABCA4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA4→partner) and Y-score (partner→ABCA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	REG3G →	+0.070	+4.459	.001	.001	3	2
BLOOD_Leukemia	AWAT2 →	+0.012	+2.799	<.001	.005	3	2
BLOOD_Leukemia	SLC36A2 →	+0.009	+2.644	.002	.008	3	2
BLOOD_Leukemia	OR10J1 →	+0.010	+3.762	<.001	.007	3	2
BREAST	ELOA3DP →	+0.040	+3.203	.005	.001	3	2
BREAST	FOXD4L6 →	+0.052	+3.477	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 177 associations by consensus.

Exploration

ABCA4 survival (RNA) · tumor vs normal (RNA) · all ABCA4 data types