Across TCGA pan-cancer cohorts, ABCA13 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of ABCA13’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where ABCA13 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ABCA13 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.
COAD are the cancer types where ABCA13 tumor–normal differential expression is most reproducible.