ABCA13

Across TCGA pan-cancer cohorts, ABCA13 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ABCA13 data layer compared with 15 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ABCA13 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ABCA13 expression acts as an unfavorable survival marker, although some lineages such as OV and LUSC show a favorable association.

UVM, KIRC, and OV are the cancer types where ABCA13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.389	0.748	<.001	146	view →
KIRC	OS	Quartile	All	0.516	0.674	<.001	81	view →
OV	OS	Quartile	III,IV	0.905	0.777	.007	80	view →
LUSC	DFS	Median	II,III,IV	0.744	0.264	<.001	71	view →
LGG	OS	Median	All	0.693	0.902	<.001	51	view →
HNSC	OS	Tertile	All	0.847	0.699	.002	51	view →
MESO	OS	Median	All	0.464	0.302	.006	26	view →
GBM	DFS	Tertile	All	0.174	0.329	<.001	21	view →
SCLC	OS	Tertile	III,IV	0.577	0.176	.008	20	view →
LUAD	OS	Tertile	All	0.615	0.218	.005	19	view →
CHOL	OS	Quartile	All	0.362	0.803	.011	16	view →
CESC	DFS	Tertile	All	0.818	0.677	.015	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ABCA13–UVM (OS)

Open the UVM breakdown →