ABCA12

Across TCGA cell cohorts, ABCA12 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,200 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ABCA12-associated GO terms across cancer lineages are Positive regulation of intracellular lipid transport, Cellular response to ketone, and Keratinocyte development. Each is linked with ABCA12 in more than 10 cancer types. Because this analysis shows association rather than direction, both ABCA12-to-partner and partner-to-ABCA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular lipid transport grouped by ABCA12-low versus ABCA12-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA12→partner) and Y-score (partner→ABCA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of intracellular lipid transport →	-0.130	-1.753	<.001	<.001	3	11
OESOPHAGUS	Cellular response to ketone →	+0.075	+1.554	<.001	.005	3	9
BLOOD_Leukemia	Keratinocyte development →	-0.749	-0.040	<.001	<.001	2	9
STOMACH	Endosome organization →	+0.076	+2.082	<.001	.002	3	8
LUNG_NSCLC_LUAD	Regulation of endoplasmic reticulum unfolded protein response →	+0.062	+1.383	<.001	<.001	3	7
BREAST	Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.109	+1.879	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,200 associations by consensus.

Positive regulation of intracellular lipid transport by ABCA12 expression — OESOPHAGUS

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