ABCA12

Across TCGA pan-cancer cohorts, ABCA12 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ABCA12 data layer compared with 13 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ABCA12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ABCA12 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRC show a favorable association.

KIRP, LIHC, and SKCM are the cancer types where ABCA12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	II,III,IV	0.174	0.776	<.001	124	view →
LIHC	DFS	Median	All	0.213	0.358	<.001	70	view →
SKCM	OS	Median	All	0.262	0.428	<.001	60	view →
UVM	DFS	Tertile	All	0.765	0.493	.006	53	view →
LGG	OS	Median	All	0.699	0.908	<.001	53	view →
KIRC	DFS	Quartile	IV	0.773	0.374	<.001	39	view →
COAD	DFS	Tertile	IV	0.269	0.543	.001	27	view →
THCA	DFS	Median	III,IV	0.561	0.799	.018	24	view →
PAAD	OS	Median	All	0.281	0.485	.014	21	view →
LUAD	OS	Quartile	All	0.252	0.449	.002	19	view →
STAD	OS	Median	III,IV	0.624	0.401	.010	14	view →
CHOL	DFS	Median	IV	0.251	0.794	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ABCA12–KIRP (OS)

Open the KIRP breakdown →