ABCA12

Across TCGA cell cohorts, ABCA12 mutation is significantly associated with the RNA expression of many other genes, with 1,234 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCA12-associated genes across cancer lineages are DVL1, C22orf46, and EPPIN. Each is linked with ABCA12 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABCA12-to-partner and partner-to-ABCA12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DVL1 grouped by ABCA12-low versus ABCA12-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA12→partner) and Y-score (partner→ABCA12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DVL1 →	+0.526	+3.074	.003	.008	3	3
LARGE_INTESTINE	C22orf46 →	+0.851	+1.706	<.001	<.001	3	3
LIVER	EPPIN →	+0.005	+2.874	<.001	.008	3	2
PANCREAS	CRYGA →	+0.025	+4.614	<.001	.004	3	2
BREAST	SLC25A52 →	+0.089	+3.621	.001	.005	3	2
BREAST	TBATA →	+0.637	+3.621	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,234 associations by consensus.

DVL1 by ABCA12 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →