ABCA1

Across TCGA patient cohorts, ABCA1 mutation is significantly associated with the RNA expression of many other genes, with 5,191 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCA1-associated genes across cancer lineages are TLE6, PAMR1, and AUNIP. Each is linked with ABCA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCA1-to-partner and partner-to-ABCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLE6 grouped by ABCA1-low versus ABCA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA1→partner) and Y-score (partner→ABCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TLE6 →	+0.501	+2.085	<.001	<.001	3	5
COAD	PAMR1 →	-0.498	-2.973	<.001	<.001	3	5
UCEC	AUNIP →	+0.434	+1.165	.001	.008	3	5
UCEC	SMC2 →	+0.502	+1.584	<.001	.001	3	5
UCEC	ERCC6L →	+0.382	+1.152	.001	.003	3	4
UCEC	LINC02765 →	+0.514	+1.475	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,191 associations by consensus.

TLE6 by ABCA1 expression — COAD

Explore this box plot interactively →