ABCA1

Across TCGA pan-cancer cohorts, ABCA1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ABCA1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ABCA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ABCA1 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

KIRC, HNSC, and COAD are the cancer types where ABCA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.749	<.001	12	view →
HNSC	Female	III,IV	+1.552	<.001	11	view →
COAD	Female	All	−0.881	<.001	11	view →
KIRP	Male	II,III,IV	+1.385	<.001	9	view →
STAD	Male	II,III,IV	+0.962	.002	6	view →
BRCA	All	III,IV	−0.889	<.001	6	view →
LUAD	Female	All	−0.531	.011	4	view →
CHOL	All	All	−1.549	<.001	3	view →
PRAD	All	All	+0.403	.013	2	view →
THCA	All	All	+0.391	.008	2	view →
LIHC	All	All	−0.364	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ABCA1–KIRC

Open the KIRC breakdown →