ABCA1

Across TCGA patient cohorts, ABCA1 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCA1-associated genes across cancer lineages are Caspase-7-cleavedD198, GSK-3_pS9, and c-Kit. Each is linked with ABCA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ABCA1-to-partner and partner-to-ABCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ABCA1-low versus ABCA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA1→partner) and Y-score (partner→ABCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.815	+2.321	<.001	.005	3	5
STAD	GSK-3_pS9 →	-0.457	-2.321	.006	.034	3	5
COAD	c-Kit →	-0.559	-2.321	.002	.032	3	4
UCEC	ATM →	-0.527	-1.765	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.576	+1.584	<.001	<.001	3	4
COAD	eIF4E →	+0.200	+1.762	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

Caspase-7-cleavedD198 by ABCA1 expression — COAD

Explore this box plot interactively →