ABCA1

Across TCGA cell cohorts, ABCA1 mutation is significantly associated with the RNA expression of many other genes, with 481 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ABCA1-associated genes across cancer lineages are SGCB, SFT2D2, and ATG4C. Each is linked with ABCA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCA1-to-partner and partner-to-ABCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGCB grouped by ABCA1-low versus ABCA1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCA1→partner) and Y-score (partner→ABCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SGCB →	+1.126	+2.489	.004	.007	3	2
BLOOD_Leukemia	SFT2D2 →	+0.509	+2.489	.002	.007	3	2
LARGE_INTESTINE	ATG4C →	+0.544	+2.628	<.001	<.001	3	2
LARGE_INTESTINE	GCH1 →	+0.499	+1.721	.002	.003	3	2
LARGE_INTESTINE	HSPG2 →	-1.105	-3.169	.002	.006	3	2
LARGE_INTESTINE	ITGB3BP →	+0.486	+2.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 481 associations by consensus.

SGCB by ABCA1 expression — BLOOD_Leukemia

Explore this box plot interactively →