AATK

Across TCGA cell cohorts, AATK mutation is significantly associated with the RNA expression of many other genes, with 441 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AATK-associated genes across cancer lineages are ACSM2A, RGS21, and HINT3. Each is linked with AATK in more than 1 cancer types. Because this analysis shows association rather than direction, both AATK-to-partner and partner-to-AATK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACSM2A grouped by AATK-low versus AATK-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AATK→partner) and Y-score (partner→AATK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ACSM2A →	+0.011	+4.417	.001	.004	3	2
SKIN	RGS21 →	+0.014	+3.425	<.001	<.001	3	2
LARGE_INTESTINE	HINT3 →	+0.593	+3.169	.008	.009	3	2
LUNG_NSCLC_LUAD	OR56A1 →	+0.224	+3.282	<.001	.001	3	2
OVARY	NBPF4 →	+1.000	+3.485	<.001	.004	3	2
LUNG_SCLC	SPANXN3 →	+0.106	+3.459	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 441 associations by consensus.

ACSM2A by AATK expression — SOFT_TISSUE

Explore this box plot interactively →