AATBC

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, AATBC mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AATBC-associated genes across cancer lineages are Notch1, MSH6, and Tuberin. Each is linked with AATBC in more than 1 cancer types. Because this analysis shows association rather than direction, both AATBC-to-partner and partner-to-AATBC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AATBC→partner) and Y-score (partner→AATBC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECNotch1 →+0.204+3.000.012.03731
UCECMSH6 →-0.410-3.000.031.03721
UCECTuberin →+0.416+2.817.007.03621
UCECA-Raf_pS299 →-0.180-3.000.009.03711
UCECMEK1 →+0.472+3.000.025.03711
UCECMSH2 →-0.276-3.000.038.03711
Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

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