Across TCGA pan-cancer cohorts, AATBC RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AATBC’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where AATBC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AATBC is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.
BLCA, LIHC, and KIRC are the cancer types where AATBC tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AATBC RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.