AASS

Across TCGA pan-cancer cohorts, AASS mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AASS data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AASS mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated AASS expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

UCEC, LSCC, and CCRCC are the cancer types where AASS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Quartile	III,IV	0.254	1.000	.005	28	view →
LSCC	OS	Tertile	II,III,IV	1.000	0.765	.007	27	view →
CCRCC	OS	Tertile	All	1.000	0.542	.010	10	view →
LUAD	OS	Median	III,IV	0.435	0.773	.008	7	view →
HNSC	DFS	Tertile	III,IV	0.939	0.726	.029	4	view →
PDAC	OS	Tertile	All	0.934	0.827	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AASS–UCEC (OS)

Open the UCEC breakdown →