AARS2

Across TCGA patient cohorts, AARS2 mutation is significantly associated with the RNA expression of many other genes, with 3,978 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AARS2-associated genes across cancer lineages are RNU4-79P, TLE6, and ACBD5. Each is linked with AARS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AARS2-to-partner and partner-to-AARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-79P grouped by AARS2-low versus AARS2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AARS2→partner) and Y-score (partner→AARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU4-79P →	+0.099	+3.734	<.001	.009	3	3
COAD	TLE6 →	+0.630	+3.472	<.001	.002	3	3
COAD	ACBD5 →	+0.620	+3.013	<.001	<.001	3	3
UCEC	CSPG5 →	+0.792	+1.747	.002	.004	3	3
COAD	EXOSC9 →	+0.532	+3.013	<.001	<.001	3	3
COAD	C12orf65 →	+0.295	+4.087	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,978 associations by consensus.

RNU4-79P by AARS2 expression — COAD

Explore this box plot interactively →