AARS2

Across TCGA patient cohorts, AARS2 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AARS2-associated genes across cancer lineages are eEF2, PDCD4, and ATM. Each is linked with AARS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AARS2-to-partner and partner-to-AARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by AARS2-low versus AARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AARS2→partner) and Y-score (partner→AARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.403	+2.459	.002	.018	3	3
UCEC	PDCD4 →	-0.725	-2.896	<.001	.001	3	3
UCEC	ATM →	-0.561	-3.459	<.001	.005	3	3
UCEC	ERK2 →	+0.226	+3.584	.001	.002	3	2
UCEC	GAPDH →	+0.438	+3.321	.029	.009	3	2
UCEC	MEK1 →	+0.539	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

eEF2 by AARS2 expression — UCEC

Explore this box plot interactively →