AARS2

Across TCGA cell cohorts, AARS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,532 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible AARS2-associated GO terms across cancer lineages are Protein-DNA complex disassembly, Regulation of DNA-templated transcription initiation, and Regulation of transcription initiation by RNA polymerase II. Each is linked with AARS2 in more than 18 cancer types. Because this analysis shows association rather than direction, both AARS2-to-partner and partner-to-AARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-DNA complex disassembly grouped by AARS2-low versus AARS2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AARS2→partner) and Y-score (partner→AARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein-DNA complex disassembly →	+0.168	+0.757	<.001	<.001	3	19
PANCREAS	Regulation of DNA-templated transcription initiation →	+0.066	+1.003	<.001	<.001	3	17
STOMACH	Regulation of transcription initiation by RNA polymerase II →	+0.059	+0.945	.001	.002	3	17
UPPER_AERODIGESTIVE_TRACT	DNA-templated transcription initiation →	+0.088	+1.007	<.001	<.001	3	17
BLOOD_Myeloma	tRNA aminoacylation for mitochondrial protein translation →	+0.144	+1.010	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Positive regulation of transcription initiation by RNA polymerase II →	+0.066	+0.745	.003	.006	2	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,532 associations by consensus.

Protein-DNA complex disassembly by AARS2 expression — BONE

Explore this box plot interactively →