AARS1

Across TCGA pan-cancer cohorts, AARS1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated AARS1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AARS1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AARS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where AARS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.860	0.266	.008	25	view →
CCRCC	OS	Quartile	III,IV	0.627	0.986	.004	19	view →
PDAC	OS	Tertile	II,III,IV	0.351	0.594	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

AARS1–HNSC (DFS)

Open the HNSC breakdown →