AARS1

Across TCGA pan-cancer cohorts, AARS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of AARS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AARS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AARS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, COAD, and THCA are the cancer types where AARS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AARS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.121	<.001	12	view →
COAD	Female	III,IV	+1.586	<.001	11	view →
THCA	Male	III,IV	−0.994	<.001	10	view →
LUAD	Male	All	+0.686	<.001	9	view →
LIHC	Male	All	+0.985	<.001	8	view →
LUSC	Female	All	+0.807	<.001	7	view →
STAD	Male	II,III,IV	+1.344	<.001	6	view →
KIRP	All	II,III,IV	+0.681	.002	6	view →
BRCA	All	II,III,IV	+0.260	.004	6	view →
CHOL	All	All	+1.257	<.001	5	view →
BLCA	Female	All	+0.825	.008	5	view →
READ	All	III,IV	+1.280	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

AARS1–HNSC

Open the HNSC breakdown →