AARS1

Across TCGA patient cohorts, AARS1 mutation is significantly associated with the RNA expression of many other genes, with 4,208 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AARS1-associated genes across cancer lineages are ZNF367, SNRNP48, and SLC7A4. Each is linked with AARS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AARS1-to-partner and partner-to-AARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF367 grouped by AARS1-low versus AARS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AARS1→partner) and Y-score (partner→AARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF367 →	+0.704	+2.321	<.001	<.001	3	3
UCEC	SNRNP48 →	+0.377	+1.890	.001	.004	3	3
UCEC	SLC7A4 →	-0.731	-1.858	.004	.002	3	3
UCEC	NDUFC1 →	+0.285	+1.701	.005	.003	3	3
UCEC	RFC5 →	+0.419	+1.627	.001	.001	3	3
UCEC	SMC2 →	+0.647	+1.606	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,208 associations by consensus.

ZNF367 by AARS1 expression — UCEC

Explore this box plot interactively →