AARS1

Across TCGA patient cohorts, AARS1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AARS1-associated genes across cancer lineages are eEF2, Acetyl-a-Tubulin-Lys40, and JNK_pT183_Y185. Each is linked with AARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AARS1-to-partner and partner-to-AARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by AARS1-low versus AARS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AARS1→partner) and Y-score (partner→AARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.311	+2.459	.008	.018	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.406	+1.392	.015	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.168	-2.087	.002	.005	3	2
UCEC	MEK1 →	+0.330	+1.925	.006	.004	3	2
UCEC	mTOR_pS2448 →	-0.137	-1.745	.005	.013	3	2
UCEC	Notch1 →	+0.112	+1.331	.015	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eEF2 by AARS1 expression — UCEC

Explore this box plot interactively →