AARS1

Across TCGA cell cohorts, AARS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,662 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AARS1-associated GO terms across cancer lineages are Regulation of translational elongation, Protein localization to chromosome, telomeric region, and L-amino acid biosynthetic process. Each is linked with AARS1 in more than 10 cancer types. Because this analysis shows association rather than direction, both AARS1-to-partner and partner-to-AARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of translational elongation grouped by AARS1-low versus AARS1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AARS1→partner) and Y-score (partner→AARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of translational elongation →	+0.108	+0.835	.001	<.001	3	11
BREAST	Protein localization to chromosome, telomeric region →	+0.095	+0.930	.001	.001	3	11
PANCREAS	L-amino acid biosynthetic process →	+0.150	+1.235	<.001	.001	3	11
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.091	+1.242	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Proteinogenic amino acid biosynthetic process →	+0.141	+1.228	<.001	<.001	3	10
LUNG_NSCLC_LUAD	Alpha-amino acid biosynthetic process →	+0.116	+1.111	<.001	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,662 associations by consensus.

Regulation of translational elongation by AARS1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →