AARS1

Across TCGA cell cohorts, AARS1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible AARS1-associated genes across cancer lineages are TPD52L3, RNASE8, and MYL10. Each is linked with AARS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AARS1-to-partner and partner-to-AARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPD52L3 grouped by AARS1-low versus AARS1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AARS1→partner) and Y-score (partner→AARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TPD52L3 →	+0.013	+4.643	<.001	.008	3	2
LARGE_INTESTINE	RNASE8 →	+0.034	+3.023	<.001	.002	3	2
BLOOD_Leukemia	MYL10 →	+0.027	+5.569	<.001	.001	3	2
LUNG_NSCLC_LUSC	DEFA6 →	+1.943	+4.643	.002	.008	3	1
LUNG_NSCLC_LUSC	LCE1D →	+0.123	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	OR5AR1 →	+0.063	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

TPD52L3 by AARS1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →