AAR2

Across TCGA patient cohorts, AAR2 mutation is significantly associated with the RNA expression of many other genes, with 2,385 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AAR2-associated genes across cancer lineages are MIR5583-1, F2, and RNU6-291P. Each is linked with AAR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AAR2-to-partner and partner-to-AAR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5583-1 grouped by AAR2-low versus AAR2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAR2→partner) and Y-score (partner→AAR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR5583-1 →	+0.699	+5.917	<.001	.001	3	2
UCEC	F2 →	+0.592	+2.902	.001	.001	3	2
LUAD	RNU6-291P →	+0.465	+3.357	.004	.007	3	2
LUAD	RNU6-739P →	+0.310	+5.924	<.001	<.001	3	2
UCEC	H4C7 →	+0.181	+2.077	<.001	.003	3	2
UCEC	ZNRF1 →	+0.458	+2.711	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,385 associations by consensus.

MIR5583-1 by AAR2 expression — COAD

Explore this box plot interactively →