AANAT

Across TCGA pan-cancer cohorts, AANAT Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated AANAT data layer compared with 23 for mass-spec protein.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher AANAT Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated AANAT expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

GBM and SKCM are the cancer types where AANAT Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.075	0.416	.011	3	view →
SKCM	DFS	Median	All	1.000	0.202	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

AANAT–GBM (OS)

Open the GBM breakdown →