AANAT

Across TCGA pan-cancer cohorts, AANAT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AANAT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where AANAT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AANAT is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, COAD, and THCA are the cancer types where AANAT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AANAT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.257	<.001	11	view →
COAD	All	III,IV	+0.270	<.001	10	view →
THCA	Male	All	−0.315	<.001	9	view →
KIRP	All	III,IV	+0.224	<.001	9	view →
LIHC	All	II,III,IV	+0.080	<.001	7	view →
HNSC	All	All	+0.148	.003	4	view →
BLCA	Male	All	+0.357	.002	3	view →
CHOL	Male	All	+0.465	<.001	2	view →
STAD	All	All	+0.253	.015	2	view →
READ	Female	All	+0.236	.035	2	view →
LUAD	All	All	+0.209	<.001	2	view →
LUSC	Male	All	+0.173	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AANAT–KIRC

Open the KIRC breakdown →