AANAT

Across TCGA patient cohorts, AANAT mutation is significantly associated with the RNA expression of many other genes, with 114 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AANAT-associated genes across cancer lineages are CCDC134, PSMD7, and ZNF174. Each is linked with AANAT in more than 1 cancer types. Because this analysis shows association rather than direction, both AANAT-to-partner and partner-to-AANAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC134 grouped by AANAT-low versus AANAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AANAT→partner) and Y-score (partner→AANAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC134 →	+0.792	+3.202	<.001	.009	3	1
UCEC	PSMD7 →	+0.862	+3.202	<.001	.009	3	1
UCEC	ZNF174 →	+0.584	+3.209	.001	.009	3	1
UCEC	GOSR2 →	+0.642	+3.218	<.001	.009	3	1
UCEC	CHKA →	+0.718	+3.223	<.001	.009	3	1
UCEC	EEF1AKMT3 →	+0.617	+3.225	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

CCDC134 by AANAT expression — UCEC

Explore this box plot interactively →