AANAT

Across TCGA cell cohorts, AANAT RNA expression is significantly associated with the go_rna of many other GO terms, with 2,320 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AANAT-associated GO terms across cancer lineages are Cytoplasmic translation, Positive regulation of protein localization to nucleus, and Negative regulation of DNA-templated transcription, elongation. Each is linked with AANAT in more than 7 cancer types. Because this analysis shows association rather than direction, both AANAT-to-partner and partner-to-AANAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic translation grouped by AANAT-low versus AANAT-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AANAT→partner) and Y-score (partner→AANAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Cytoplasmic translation →	+0.096	+0.390	<.001	<.001	3	7
BREAST	Positive regulation of protein localization to nucleus →	+0.097	+0.407	<.001	<.001	3	7
LARGE_INTESTINE	Negative regulation of DNA-templated transcription, elongation →	+0.084	+0.190	<.001	.004	3	7
PANCREAS	Regulation of protein localization to nucleus →	+0.083	+0.430	<.001	<.001	3	7
BREAST	Positive regulation of chromosome organization →	+0.058	+0.382	.001	<.001	3	7
BREAST	Spliceosomal complex assembly →	+0.072	+0.319	<.001	.002	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,320 associations by consensus.

Cytoplasmic translation by AANAT expression — BREAST

Explore this box plot interactively →