AAMP

Across TCGA patient cohorts, AAMP mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AAMP-associated genes across cancer lineages are C-Raf, MEK1, and p62 Lck ligand. Each is linked with AAMP in more than 1 cancer types. Because this analysis shows association rather than direction, both AAMP-to-partner and partner-to-AAMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by AAMP-low versus AAMP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAMP→partner) and Y-score (partner→AAMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.180	+3.321	.016	.010	3	2
UCEC	MEK1 →	+0.380	+3.000	.047	.036	2	1
UCEC	p62 Lck ligand →	+0.466	+2.817	.006	.036	2	1
UCEC	Cyclin-B1 →	+0.754	+3.321	.010	.010	2	1
UCEC	4E-BP1 →	+0.426	+3.321	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C-Raf by AAMP expression — UCEC

Explore this box plot interactively →