AAMP

Across TCGA pan-cancer cohorts, AAMP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of AAMP’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AAMP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AAMP is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, KICH, and LIHC are the cancer types where AAMP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AAMP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.315	<.001	10	view →
KICH	Female	II,III,IV	−1.617	<.001	9	view →
LIHC	All	III,IV	+0.721	<.001	9	view →
THCA	All	IV	−0.509	<.001	9	view →
HNSC	Male	All	+0.447	<.001	8	view →
LUSC	Male	All	+0.615	<.001	7	view →
LUAD	All	III,IV	+0.385	<.001	7	view →
STAD	Male	II,III,IV	+0.869	<.001	6	view →
KIRC	Female	All	+0.368	<.001	6	view →
CHOL	Female	All	+1.563	<.001	5	view →
PAAD	All	All	+0.572	.007	4	view →
READ	Female	All	+0.546	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

AAMP–COAD

Open the COAD breakdown →