AAMP

Across TCGA cell cohorts, AAMP mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AAMP-associated genes across cancer lineages are GML, LGI1, and MMP27. Each is linked with AAMP in more than 1 cancer types. Because this analysis shows association rather than direction, both AAMP-to-partner and partner-to-AAMP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GML grouped by AAMP-low versus AAMP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAMP→partner) and Y-score (partner→AAMP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.075	+4.152	<.001	.009	3	1
BLOOD_Leukemia	LGI1 →	+0.099	+6.124	<.001	<.001	3	1
BLOOD_Leukemia	MMP27 →	+0.019	+4.969	<.001	.003	3	1
BLOOD_Leukemia	KERA →	+0.006	+4.551	.002	.004	3	1
BLOOD_Leukemia	OR11H6 →	+0.028	+4.705	<.001	.003	3	1
BLOOD_Leukemia	SCGB1C1 →	+0.098	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

GML by AAMP expression — BLOOD_Leukemia

Explore this box plot interactively →