AAK1

Across TCGA pan-cancer cohorts, AAK1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated AAK1 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AAK1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AAK1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where AAK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.900	0.671	.004	14	view →
LUAD	OS	Tertile	II,III,IV	0.314	0.792	.018	4	view →
PDAC	OS	Median	IV	0.937	0.395	.026	3	view →
GBM	OS	Quartile	All	0.329	0.681	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

AAK1–HNSC (DFS)

Open the HNSC breakdown →