AAK1

Across TCGA cell cohorts, AAK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,079 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AAK1-associated GO terms across cancer lineages are Cytosolic transport, Negative regulation of autophagy, and Process utilizing autophagic mechanism. Each is linked with AAK1 in more than 15 cancer types. Because this analysis shows association rather than direction, both AAK1-to-partner and partner-to-AAK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytosolic transport grouped by AAK1-low versus AAK1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AAK1→partner) and Y-score (partner→AAK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.086	+1.029	<.001	<.001	3	16
STOMACH	Negative regulation of autophagy →	+0.101	+1.091	<.001	.003	3	16
STOMACH	Process utilizing autophagic mechanism →	+0.068	+1.026	<.001	<.001	3	16
STOMACH	Autophagy →	+0.068	+1.026	<.001	<.001	3	16
SKIN	Vacuole organization →	+0.062	+0.839	<.001	<.001	3	16
STOMACH	Retrograde transport, endosome to Golgi →	+0.096	+1.100	.001	.009	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,079 associations by consensus.

Cytosolic transport by AAK1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →