AAGAB

Across TCGA patient cohorts, AAGAB mutation is significantly associated with the RNA expression of many other genes, with 1,788 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AAGAB-associated genes across cancer lineages are RNU6-448P, MIR3617, and MIR8070. Each is linked with AAGAB in more than 1 cancer types. Because this analysis shows association rather than direction, both AAGAB-to-partner and partner-to-AAGAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-448P grouped by AAGAB-low versus AAGAB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAGAB→partner) and Y-score (partner→AAGAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-448P →	+0.460	+5.408	<.001	.002	3	2
BLCA	MIR3617 →	+0.528	+4.685	<.001	<.001	3	2
BLCA	MIR8070 →	+0.741	+3.623	<.001	.004	3	2
UCEC	RNU6-1318P →	+0.323	+2.899	<.001	.003	3	2
UCEC	RNU6-42P →	+0.576	+2.571	.007	.004	3	2
UCEC	TRAJ28 →	+0.451	+2.132	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,788 associations by consensus.

RNU6-448P by AAGAB expression — SKCM

Explore this box plot interactively →