AADACL3

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, AADACL3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AADACL3-associated genes across cancer lineages are Notch1, mTOR_pS2448, and PTEN. Each is linked with AADACL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AADACL3-to-partner and partner-to-AADACL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AADACL3→partner) and Y-score (partner→AADACL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECNotch1 →+0.228+3.009.001.01932
SKCMmTOR_pS2448 →-0.179-2.321.047.03532
SKCMPTEN →-0.470-3.169.014.01832
UCECEGFR_pY1068 →-0.255-2.321.043.03531
UCECp62 Lck ligand →+0.480+2.999.003.03531
UCECPCNA →+0.261+2.321.016.03422
Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration