Across TCGA pan-cancer cohorts, AADACL3 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of AADACL3’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where AADACL3 RNA is repressed in tumor relative to normal tissue. In most cancer types AADACL3 is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.

BRCA, KIRC, and HNSC are the cancer types where AADACL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AADACL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	−0.170	<.001	6	view →
KIRC	All	II,III,IV	−0.003	.011	6	view →
HNSC	Male	III,IV	+0.013	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: AADACL3 RNA expression & survival · all AADACL3 data types