Across TCGA cell cohorts, AADACL3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AADACL3-associated genes across cancer lineages are ASZ1, CFHR2, and MMP26. Each is linked with AADACL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AADACL3-to-partner and partner-to-AADACL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AADACL3→partner) and Y-score (partner→AADACL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASZ1 →	+0.145	+4.152	<.001	.009	3	1
BLOOD_Leukemia	CFHR2 →	+0.306	+6.124	<.001	<.001	3	1
SKIN	MMP26 →	+0.020	+5.022	<.001	.002	3	1
LARGE_INTESTINE	ASPN →	+0.045	+3.648	<.001	.002	3	1
LARGE_INTESTINE	RSC1A1 →	+0.882	+3.285	.001	.007	3	1
LARGE_INTESTINE	MSH4 →	+0.240	+3.464	.005	.004	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

AADACL3 survival (RNA) · tumor vs normal (RNA) · all AADACL3 data types