AADACL2-AS1

Across TCGA pan-cancer cohorts, AADACL2-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated AADACL2-AS1 data layer compared with 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher AADACL2-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AADACL2-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LIHC show a favorable association.

COAD, THYM, and BRCA are the cancer types where AADACL2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	0.407	0.639	<.001	63	view →
THYM	OS	Tertile	All	0.784	0.993	<.001	51	view →
BRCA	OS	Quartile	All	0.985	0.943	.001	47	view →
DLBC	DFS	Tertile	II,III,IV	0.065	0.829	<.001	45	view →
STAD	DFS	Quartile	IV	0.132	0.529	.001	32	view →
THCA	OS	Tertile	III,IV	0.926	0.991	.003	27	view →
LGG	OS	Tertile	All	0.314	0.467	.002	21	view →
LIHC	DFS	Median	III,IV	0.300	0.086	.004	20	view →
UCS	DFS	Median	IV	0.981	0.450	.004	18	view →
MESO	DFS	Tertile	IV	0.079	0.414	.004	18	view →
LUSC	OS	Tertile	All	0.810	0.719	.008	15	view →
HNSC	OS	Quartile	All	0.621	0.777	.010	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

AADACL2-AS1–COAD (DFS)

Open the COAD breakdown →