AADACL2-AS1

Across TCGA pan-cancer cohorts, AADACL2-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of AADACL2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where AADACL2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types AADACL2-AS1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, COAD, and BRCA are the cancer types where AADACL2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AADACL2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	II,III,IV	−0.708	<.001	10	view →
COAD	Male	All	+0.267	<.001	8	view →
BRCA	Female	II,III,IV	−0.589	<.001	6	view →
LUAD	All	II,III,IV	−0.408	.003	4	view →
STAD	Female	III,IV	+0.485	<.001	3	view →
READ	All	III,IV	+0.415	.035	3	view →
KICH	All	All	−0.030	.008	2	view →
LUSC	All	All	+0.424	.035	1	view →
HNSC	Male	III,IV	+0.380	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

AADACL2-AS1–THCA

Open the THCA breakdown →