AAAS

Across TCGA pan-cancer cohorts, AAAS mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated AAAS data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher AAAS mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated AAAS expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where AAAS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	II,III,IV	0.593	0.940	.001	48	view →
LSCC	DFS	Quartile	II,III,IV	0.852	0.378	.005	30	view →
PDAC	DFS	Tertile	All	0.307	0.540	.003	24	view →
HNSC	DFS	Median	III,IV	0.903	1.000	.004	17	view →
GBM	DFS	Tertile	All	0.440	0.270	.019	8	view →
UCEC	DFS	Quartile	All	0.856	1.000	.005	6	view →
LUAD	OS	Median	All	0.957	0.801	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

AAAS–CCRCC (OS)

Open the CCRCC breakdown →