AAAS

Across TCGA pan-cancer cohorts, AAAS RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of AAAS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where AAAS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AAAS is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, COAD, and HNSC are the cancer types where AAAS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AAAS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.474	<.001	12	view →
COAD	Male	IV	+1.030	<.001	11	view →
HNSC	Male	All	+0.628	<.001	11	view →
LIHC	Female	II,III,IV	+1.344	<.001	9	view →
KIRP	All	II,III,IV	+0.656	<.001	9	view →
BLCA	All	All	+0.653	<.001	8	view →
LUAD	All	All	+0.245	<.001	8	view →
LUSC	Male	II,III,IV	+0.863	<.001	7	view →
THCA	Male	III,IV	−0.392	.006	7	view →
STAD	All	II,III,IV	+0.692	<.001	6	view →
UCEC	All	III,IV	+0.536	.008	6	view →
CHOL	All	All	+1.574	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

AAAS–KIRC

Open the KIRC breakdown →