AAAS

Across TCGA patient cohorts, AAAS protein abundance is significantly associated with the RNA expression of many other genes, with 18,062 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AAAS-associated genes across cancer lineages are TRIP13, NDC1, and TTK. Each is linked with AAAS in more than 8 cancer types. Because this analysis shows association rather than direction, both AAAS-to-partner and partner-to-AAAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AAAS versus TRIP13 in BRCA, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAAS→partner) and Y-score (partner→AAAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRIP13 →	+0.948	+0.270	<.001	<.001	3	9
LSCC	NDC1 →	+0.736	+0.229	<.001	<.001	3	8
LSCC	TTK →	+1.073	+0.198	<.001	<.001	3	8
HNSC	CENPA →	+1.012	+0.236	<.001	<.001	3	8
UCEC	CENPF →	+1.649	+0.232	<.001	<.001	3	8
BRCA	NCAPH →	+0.961	+0.360	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,062 associations by consensus.

AAAS vs TRIP13 — BRCA

Explore this scatter interactively →