AAAS

Across TCGA patient cohorts, AAAS mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AAAS-associated genes across cancer lineages are Notch1, eEF2, and ERK2. Each is linked with AAAS in more than 1 cancer types. Because this analysis shows association rather than direction, both AAAS-to-partner and partner-to-AAAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by AAAS-low versus AAAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AAAS→partner) and Y-score (partner→AAAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.182	+1.906	.001	.016	3	2
UCEC	eEF2 →	+0.335	+2.321	.019	.034	3	1
UCEC	ERK2 →	+0.170	+2.459	.028	.018	3	1
UCEC	GATA6 →	-0.143	-2.321	.025	.034	3	1
UCEC	INPP4B →	-0.282	-2.321	.030	.033	3	1
UCEC	JNK2 →	+0.257	+2.415	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Notch1 by AAAS expression — UCEC

Explore this box plot interactively →