AAAS

Across TCGA cell cohorts, AAAS RNA expression is significantly associated with the go_rna of many other GO terms, with 5,071 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AAAS-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Telomere maintenance, and Meiotic chromosome separation. Each is linked with AAAS in more than 14 cancer types. Because this analysis shows association rather than direction, both AAAS-to-partner and partner-to-AAAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by AAAS-low versus AAAS-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AAAS→partner) and Y-score (partner→AAAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.179	+0.772	.002	.006	3	15
BONE	Telomere maintenance →	+0.087	+0.778	<.001	<.001	3	15
BONE	Meiotic chromosome separation →	+0.447	+0.706	.004	<.001	3	15
BONE	Telomere organization →	+0.084	+0.716	<.001	.002	3	14
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.199	+0.886	.003	.001	3	14
BONE	Interstrand cross-link repair →	+0.076	+0.791	.003	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,071 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by AAAS expression — BONE

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